Design of Lipid-Based Formulations for Oral Administration of Poorly Water-Soluble Drug Fenofibrate: Effects of Digestion
نویسندگان
چکیده
منابع مشابه
Lipid‐Based Nano‐Delivery for Oral Administration of Poorly Water Soluble Drugs (PWSDs): Design, Optimization and in vitro Assessment
Currently, more than 90% of compounds identified are water insoluble and or poorly water soluble, which is a bottle neck in the development of many new drug candidates. These poorly soluble drug molecules are difficult to formulate using conventional approaches and are associated with numerous formulation‐related performance issues. Formulating these compounds using lipid‐based systems is one o...
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Clinical studies with oral lipid based formulations of poorly soluble compounds
This work is an attempt to give an overview of the clinical data available on lipid based formulations. Lipid and surfactant based formulations are recognized as a feasible approach to improve bioavailability of poorly soluble compounds. However not many clinical studies have been published so far. Several drug products intended for oral administration have been marketed utilizing lipid and sur...
متن کاملNovel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate
PURPOSE The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate. METHODS Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP) and Labrafil(®) M 2125 as carriers using the electrospray technique, and the e...
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The objective of this study was to develop nanoemulsion formulations for enhancement of oral bioavailability of paclitaxel, a model hydrophobic drug and P-glycoprotein substrate. The oil-in-water (o/w) nanoemulsions were made with pine nut oil as the internal oil phase, egg lecithin as the primary emulsifier, and water as the external phase. Stearylamine and deoxycholic acid were used to impart...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2012
ISSN: 1530-9932
DOI: 10.1208/s12249-012-9787-2